Synthesis and Biological Evaluation of 2-Phenyl Benzothiazole Derivatives as Cytotoxic Agents

Authors

  • A. Foroumadi 4Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran
  • A. Mokhtari Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran
  • L. Firoozpour Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran
  • M. Safavi Department of Biotechnology, Iranian Research Organization for Science and Technology, Tehran 33535-111, Islamic Republic of Iran
  • S. Moghimi Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran
Abstract:

Cancer is a leading cause of death worldwide. Many heterocyclic cores are present in the structures of clinically approved anticancer drugs. Meanwhile, benzothiazoles have been reported as one of the most important heterocyclic scaffolds in previously reported anticancer agents in the literature. Therefore, in this report, a novel series of 2-phenyl benzothiazole derivatives was synthesized, biologically evaluated against breast cancer cell line (T47D) and compared with etoposide as a reference drug.  The anticancer activities were evaluated by MTT colorimetric assay. Among all tested compounds, N-(4-(6-methoxybenzo[d]thiazol-2-yl)phenyl)acetamide illustrated the most potent cytotoxic activity.

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Journal title

volume 29  issue 4

pages  335- 340

publication date 2018-10-01

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